Psoriatic arthritis (PsA) is an autoimmune diseaseCLOSE Autoimmune disease: a disease that happens when a person’s immune system attacks their own body. that affects different parts of the body. When this happens, you may experience various symptoms, including joint pain, swelling, and skin lesions. Sometimes these symptoms develop at the same time, and sometimes they can happen separately over a period of time. Read on to learn more about PsA.